Open competition for the PhD Student position in the National Science Centre funded project
Project information:
Project leader: dr hab. Michał Komorowski
Source of funding: National Science Centre, OPUS 20: Cell-to-cell heterogeneity of cross-wired cytokine signaling: filling the gaps between molecular origins and translational implications
Implementing institution: Institute of Fundamental Technological Research Polish Academy of Sciences
Position: PhD Student
Project duration: 2021/09/30 - 2025/09/29
Deadline for applications: 19.10.2022
Project description:
In multicellular organisms like the human body, trillions of cells of multiple different cell types communicate with each other by releasing a thousand types of molecules. However, the functioning of biochemical signaling does not seem to comply with the principles of communication engineering. An engineer designing a
system would linearly connect sensors with receivers ensuring reproducible transmission. Cells, however, have many cross-wired signaling pathways (one sensor connected to many receivers and one receiver connected to many sensors) that produce highly variable signals.
How can cells function reliably with highly variable signaling?
What are the implications of variable cross-wired signaling for health and disease?
What is the explanation for such a “messy” architecture?
We are using a variety of experimental (e.g., high-throughput immunostaining and smRNA FISH, live microscopy imaging) and theoretical approaches (e.g., data analysis techniques and information theory) to address the above questions. Currently, we are seeking a highly motivated PhD student with a background in mathematics, statistics, engineering, computer science, or related field to help us on the way.
For more information visit our website sysbiosig.org, or email the group leader, Michał Komorowski (Ten adres pocztowy jest chroniony przed spamowaniem. Aby go zobaczyć, konieczne jest włączenie w przeglądarce obsługi JavaScript.).
Expected qualifications:
- high motivation for scientific work at the interface between mathematics and cell biology
- MSc in biology, bioinformatics, computer sciences or related filed
- programming skills (particularly Python, R, Matlab and/or C++)
- fluent english
- ability to work in a team
We offer:
- exciting research tasks
- support in developing new skills
- PhD studentship of 2700 PLN
- participation in international conferences and workshops
- support in application for additional funding and scholarships
- highly creative, innovative and friendly work environment
- international collaborations
Responsibilities:
- development of statistical tools directly for handling and analysis of large data sets
- development of statistical models of cellular signalling
- close collaboration with experimental biologists
How to apply?
Email CV including MSc track record, a letter of motivation and two contacts for references.
Please include in your CV the following clause: "I agree to the processing of personal data contained in my job offer for the needs necessary to carry out the recruitment process conducted by IPPT PAN with headquarters in Warsaw, ul. A. Pawińskiego 5B, according to art. 13 para. 1 and 2 of Regulation (EU) 2016/679 of the Parliament and of the Council of 27 April 2016 on the protection of individuals with regard to the processing of personal data and the free movement of such data and the repeal of Directive 95/46 / EC (RODO).
Contact: Dr Michał Komorowski (Ten adres pocztowy jest chroniony przed spamowaniem. Aby go zobaczyć, konieczne jest włączenie w przeglądarce obsługi JavaScript.)